Liver Cancer in Singapore Info

The functions of the liver is to filter the blood that circulates through the body and convert the nutrients and drugs absorbed from the digestive tract into ready-to-use chemicals. Furthermore, it has many other important functions such as removing toxins and other chemical waste products from the blood and readying them for excretion, which means that it plays an important role in our life. It starts in the liver. If there is an uncontrolled growth of cancer cells that form a malignant tumor in the liver, it will happen to you. When you experience this cancer, this cancer in Singapore can give you a help.

The liver cancer in Singapore has the capability of diagnosing liver cancer by taking a thorough personal and family medical history such as the symptoms and risk factors for it. The goal of the tests is to help the doctors to determine how well the liver is functioning. There are many imaging tests that create a picture of the liver, including a CT scan, ultrasound, MRI, or an angiogram. To some extent, the doctor will use a liver biopsy to have diagnostic testing. Some patients with the disease don't realize that this cancer has come to them until it progresses.

The liver cancer in Singapore will support the people to have the cancer screening that can prevent it happening. You have to know that the cost of treating patients with liver disease rises rapidly as the disease progresses. Therefore, the treatment in the early stage not only can help you save your life but also can help you reduce the burden. It can cause many symptoms such as weight loss , loss of appetite , nausea , fatigue , and bloating , and fever, which can make you feel miserable, affecting your normal life, even bringing more inconvenience to your family.

The liver cancer in Singapore can provide you with a combination of surgery, chemotherapy, radiation therapy and transplant. When your disease has reached the end stage, they will recommend you to have the liver transplant. The transplant has become popular with both the doctors and the patients. The hospital in Singapore has many professional surgeons and advanced equipments as well as a good environment for recuperating. There are many countries to call for calling for more people to get the cancer screening so that it can result in the chances of survival for people at high risk.

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Griffin Hill has published 73 articles. Article submitted on July 19, 2013. Word count: 402

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Treatment for Liver Failure

The liver failure means that cannot function as it should before. As an important organ in the body, the liver works to detoxify and excrete a variety of substances consumed in the diet and waste products of our body's metabolism as well as produce the proteins necessary for the clotting of the blood and a protein called albumin. This disease becomes the fifth biggest killer in the UK. Generally, it causes no warning signs until it is far advanced. The most important thing that you have to notice is that most of us don't realize that they can have the potentially fatal condition.

The liver failure will lead to some symptoms, including dull pain or feeling of fullness in the upper right abdomen, below the rib cage, poor appetite, fatigue, nausea, vomiting, low grade fever, abdominal swelling and pale stool or white diarrhea - loose, foul smelling bowel movements that may float and stick to the toilet. Some people may suffer from the enlarged liver detected by palpation, yellow discoloration of the eye (sclera) and skin. These symptoms can help the doctors to determine whether you have this disease so that they will ask you about these symptoms during the diagnosis.

Everybody should know about some conditions that will increase the risks of the liver failure. As long as you know the causes, you will take some measurements to prevent them. This disorder can be affected by the alcoholism, diabetes and obesity and a high-fat diet. Therefore, it is important to stopping drinking alcohol. And the patients may be recommended to eat a diet that can be high in carbohydrate, low in protein, low in fat diet, and low in sodium. When the liver disease is not so bad, the doctors will give you drugs to help control some of the complications of the ailing liver.

When the liver failure become worse, the patients have to go in for the liver transplant. This solution is the most effective and safe treatment for disease. It includes two types such as the cadaveric transplantation and living donor transplantation. With the limited number of cadaveric donation, many patients with end-stage liver disease are waiting for liver transplantation and died during the waiting. Therefore, they may encounter the death during the waiting. However, the living donor liver can overcome this problem, bring hope to the patients. Anyway, every patients should focus on the symptoms, causes and the treatment of this disease.

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New Evidence For The Genetic Bases Of Liver Cancer

Main Category: Liver Disease / Hepatitis
Also Included In: Cancer / Oncology;??Genetics
Article Date: 03 Jul 2013 - 1:00 PDT Current ratings for:
New Evidence For The Genetic Bases Of Liver Cancer

The Asian Cancer Research Group (ACRG), an independent, not-for-profit company in collaboration with BGI, the world's largest genomics organization, and The University of Hong Kong (HKU), jointly announced the publication of findings from a study of recurrent mutations in hepatocellular carcinoma (HCC), one of the most deadly cancers worldwide, in the international journal Genome Research . The study provides new insights into potential therapeutic intervention strategies for this common form of liver cancer.

HCC is a primary malignancy of the hepatocytes, generally leading to death within 6-20 months after diagnosis. This type of cancer is more common in parts of Africa and Asia, where the patients with hepatitis B or C are at risk for liver cancer, even if they have not developed cirrhosis. HCC has limited treatment options such as surgical resection of the tumor at its early stage, and the molecular basis of its occurrence and development remains poorly understood.

In this study, researchers used whole genome sequencing (WGS) to survey a cohort of 88 matched HCC tumor and normal samples from Hong Kong for investigating alerted genes and the pathways implicated in HBV-associated HCC. They found that TP53 was the most commonly mutated tumor suppressor gene, accounting for 35.2% in the HCC cohort. Generally, the patients with tumors containing TP53 mutations exhibited poor survival.

The Wnt/β-Catenin signaling pathway is central for liver functions and is frequently abnormal activated in the carcinogenesis of HCC. Researchers in this study found β-catenin maybe the most frequently mutated oncogene. In addition to β-catenin, they found relative high mutation rates in genes in the JAK/STAT pathway, which may act as a major oncogenic driver in HCC tumor progression.

Hancheng Zheng, group leader of this project at BGI, said, "Liver cancer is intractable to nearly all currently available anti-cancer targeted therapies. Our findings in this study provide a better understanding of molecular basis of hepatocarcinogenesis and provide new clues to improving the diagnosis and treatment of liver cancer in the future."

"We detected a series of genes and pathways implicated in HBV-associated HCC using whole genome sequencing, which contribute to a better understanding of the tumor biology and targeted drug screening," said Dr. James Hardwick, Vice President of ACRG, and Director of Informatics & Analysis at Merck, "The ACRG was established to fuel research directed towards improving our understanding of cancers affecting Asian populations. By working together, we are able to generate important breakthroughs that can be transformed to better fight against liver cancer in the future."

"As clinicians, we are very excited about the several prevalent and actionable mutations identified from the study, including activating mutations of JAK1, which warrant testing several existing inhibitors for the treatment of the disease preclinically and clinically," said Dr. Ronnie Poon, Chair Professor and Chief, Division of Hepatobiliary and Pancreatic Surgery, The University of Hong Kong.

Article adapted by Medical News Today from original press release. Click 'references' tab above for source.
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