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Showing posts with label Interaction. Show all posts
Showing posts with label Interaction. Show all posts

Tuesday, June 4, 2013

Social Interaction Can Help Relieve Breast Cancer Symptoms

Editor's Choice
Main Category: Breast Cancer
Also Included In: Cancer / Oncology
Article Date: 12 May 2013 - 0:00 PDT
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Social Interaction Can Help Relieve Breast Cancer Symptoms
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Breast cancer patients who have lots of friends and social relationships tend to cope with the pain and other symptoms associated with the disease better than those who are more isolated, according to new research published in the journal Breast Cancer Research and Treatment.

Lead author of the study Candyce H. Kroenke, ScD, MPH, staff scientist with the Kaiser Permanente, Division of Research, said:

"This study provides research-based evidence that social support helps with physical symptoms. Social support mechanisms matter in terms of physical outcomes."

Breast cancer is a kind of cancer that develops from breast cells. Malignancy usually starts off in the inner lining of milk ducts or the lobules that supply them with milk.

Breast cancer accounts for 16% of all female cancers and 22.9% of invasive cancers in women.

As the first study of its kind to assess the effects of social interaction among cancer patients, the researchers were able to identify the benefits of having friends and engaging in social interaction with them.

In conclusion, the researchers found that breast cancer patients who engaged in more conversation and interaction in general, were able to cope with their symptoms better than those who didn't.

In addition, they found that women who had help around the house were also more able to cope with their symptoms.

Korenke said:

"While hundreds of studies have examined the role of factors influencing cancer risk and prevention, this study is one of a small but growing number that focus on quality of life after a breast cancer diagnosis."

A total of 3,139 women who were diagnosed with breast cancer participated in the study conducted by researchers at the Kaiser Permanente Division of Research in California. They analyzed what effect social interaction had on the participants' ability to cope with symptoms that are associated with the breast cancer.

Participants were asked about their social networks such as the number of friends they had, the support they received from relatives and social and community ties.

The authors found that those who had more contact with their friends or family were at a better position to deal with their symptoms. Being able to do fun things with friends helped the patients in many ways. Apart from giving them moral support, the interaction was found to help alleviate physical symptoms of the disease.

Women with the largest social networks or personal relationships reported the best overall quality of life during their breast cancer treatment. Higher levels of support was associated with better emotional well-being too.

Of the types of social interaction, positive social interaction in particular (such as the availability of other people to do fun things with) was associated with the best quality of life.

Women with little social interaction were more likely to report a low quality of life.

Kroenke and co-authors wrote:

"Positive social interaction was significantly related to every quality-of-life measure. Given that this dimension was determined by the availability of someone with whom to have fun, relax and get one's mind off things for awhile, it is possible that positive social interaction may enable women to forget for a while the distress of being a cancer patient, and the physiologic effects last beyond the actual interaction."

Women who didn't receive tangible support, which included doing chores or providing food, were 2.74 percent more likely to report a lower quality of life compared to those who did.

As more women are being cured of breast cancer, it is imperative that their quality of life following treatment improves too.

A previous study published in Cancer Prevention Research, a journal of the American Association for Cancer Research, revealed that social environment can play an important role in the biology of disease, including breast cancer, and can lead to significant differences in health outcome.

Written by Joseph Nordqvist
Copyright: Medical News Today
Not to be reproduced without permission of Medical News Today

Visit our breast cancer section for the latest news on this subject. "Social networks, social support mechanisms, and quality of life after breast cancer diagnosis"
Candyce H. Kroenke et al
Breast Cancer Research and Treatment May 2013. DOI:10.1007/s10549-013-2477-2 Please use one of the following formats to cite this article in your essay, paper or report:

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13 May. 2013. APA

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Saturday, June 1, 2013

Blocking The Protein-Protein Interaction Which Causes Ewing Sarcoma

Main Category: Cancer / Oncology
Also Included In: Genetics
Article Date: 17 May 2013 - 0:00 PDT Current ratings for:
Blocking The Protein-Protein Interaction Which Causes Ewing Sarcoma
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Continuous infusion of a novel agent not only halted the progression of Ewing sarcoma in rats, while some tumors also regressed to the point that cancer cells could not be detected microscopically, say researchers at Georgetown Lombardi Comprehensive Cancer Center. Their study, which will be presented at the 2013 annual meeting of the American Society of Clinical Oncology*, provides pre-clinical evidence necessary to initiate a clinical trial.

"This agent has the potential to be more effective, and considerably less toxic, than the current drugs now used to treat this rare cancer," says the study's lead investigator, Jeffrey Toretsky, MD, a pediatric oncologist and researcher at Georgetown Lombardi, part of Georgetown University Medical Center.

The agent, (S)-YK-4-279, was developed by Toretsky and his colleagues, including scientists in GUMC's Center for Drug Discovery. Based on early promising studies of the compound, Toretsky established TDP Biotherapeutics, Inc. to manufacture the agent. Toretsky says TDP Biotherapeutics, Inc. is preparing a U.S. Food and Drug Administration (FDA) investigational new drug (IND) application for (S)-YK-4-279 so that a clinical trial can be initiated.

In the United States, about 500 children and young adults are diagnosed with the cancer annually, and they are treated with a combination of five different chemotherapy drugs. Between 60 to 70 percent of patients survive more than five years, but with many late effects from therapy. Few treatments lead to a cure for patients whose cancer progresses, Toretsky says.

Ewing sarcoma is caused by the exchange of DNA between two chromosomes. The resulting EWSR1-FLI1 gene produces a fusion protein, EWS-FLI1, responsible for development of the cancer. In 2006, Toretsky and his team discovered that the fusion protein binds to another protein, RNA helicase A (RHA), which is important for cancer progression.

The (S)-YK-4-279 agent they developed is considered unique because it stops the two proteins - EWS-FLI1 and RHA - from interacting. "Scientists have long thought it impossible to block protein-protein interaction because the surface of these proteins are too slippery and flexible for a drug to bind to," Toretsky says. "Our agent challenges that conventional thinking."

To test the agent, the researchers developed a rat model of Ewing sarcoma and figured out how to deliver a continuous drip of the drug to the animals. "We found that cancer cells need a continuous exposure at low concentrations for the drug to be of maximum effectiveness," Toretsky says. "And this strategy works extremely well in these animal models. The drug appears to be very successful."

Toretsky is an inventor on a patent application that has been filed by Georgetown University related to the technology described. He has an ownership interest in TDP Biotherapeutics, to which the technology has been licensed for research and development.

Article adapted by Medical News Today from original press release. Click 'references' tab above for source.
Visit our cancer / oncology section for the latest news on this subject. ASCO Annual Meeting: May 31-June 4, 2013 | McCormick Place | Chicago, Illinois

The FDA has granted the TDP Biotherapeutics company orphan drug status (Orphan Drug Act), which qualifies the sponsor of a product to receive tax credit and marketing incentives. The study was funded by a grant from the National Cancer Institute (RC4 CA156509) issued under the American Recovery and Reinvestment Act (R01CA138212).

Georgetown University Medical Center

Please use one of the following formats to cite this article in your essay, paper or report:

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Georgetown University Medical Center. "Blocking The Protein-Protein Interaction Which Causes Ewing Sarcoma." Medical News Today. MediLexicon, Intl., 17 May. 2013. Web.
20 May. 2013. APA

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'Blocking The Protein-Protein Interaction Which Causes Ewing Sarcoma'

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All opinions are moderated before being included (to stop spam)

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For any corrections of factual information, or to contact the editors please use our feedback form.

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Note: Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a health care professional. For more information, please read our terms and conditions.



View the original article here